Webinar

Rigor, Reproducibility, and Quality Improvement of Clinical Trials

Livestreamed Wednesday, June 25, 2025

Registrants will receive an email with a link to access the webinar after completion of registration.

Rigor, Reproducibility, and Quality Improvement of Clinical Trials

Growing public expectations and the new factor-based grant application review criteria for most research project grant activity codes significantly raise the bar for clinical trials. NIH leaders repeatedly underscore the expectation that science, especially publicly funded research, should be replicable and generalizable.

The aims of this webinar are the following:

• to identify the most significant threats to the integrity and reproducibility of clinical trials
• to offer the latest recommendations for prevention of serious quality defects
• to recommend designs for reproducible, generalizable, and informative clinical research

This webinar is developed to support clinical researchers and their teams, teachers of reproducibility in research education and mentored research career development programs, research universities and institutions, industry supported researchers, and funders of research projects in life sciences.

With thanks to our sponsor

• Agenda

• Speakers

Welcome and Goals
Andrew Balas, MD, PhD, President, Friends of the NLM
(Biomedical Research Innovation Laboratory, Augusta University)

Evolution of expectations from randomized clinical trials
Scott Podolsky, MD (Harvard University)

What makes a clinical trial an (un)reliable source of evidence?
Gordon Guyatt, PhD (McMaster University)

Q/A

STANDARDS, PLATFORMS, AND QUALITY CONTROL PANEL
Introduction

Recent updates and expectations of the CONSORT, SPIRIT, and PRISMA guidelines
David Moher, PhD, FRSC, FCAHS (University of Ottawa)

Advanced information platforms for conducting quality clinical trials
Derk Arts, MD, PhD (Castor, New York-Amsterdam)

Persistence and trial quality control in low resource environments
James Berkley, MBBS, MTropMed, MRCP, MD, FRCPCH, FMedSci (KEMRI | Wellcome Trust)

Methods, data and software transparency for clinical trials
Nicholas DeVito, PhD (Bennett Institute for Applied Data Science, Oxford)

Q/A

	Andrew Balas, MD, PhD Andrew Balas MD, PhD is a Professor of Public Health at Augusta University, Vice President of the Friends of the NIH National Library of Medicine, member of the American College of Medical Informatics and elected member of the European Academy of Sciences and Arts. His studies about delay and waste in the transfer of research results to health care are frequent reference points in translational research initiatives. The results have been cited by many researchers, policy-makers, and the President of the United States. Currently, he leads the Biomedical Research Innovation Laboratory, a team of researchers conducting ‘science of science’ studies.
	Derk Arts, MD, PhD Castor, New York–Amsterdam
	Gordon Guyatt, PhD McMaster University
	James Berkley, MBBS, MTropMed, MRCP, MD, FRCPCH, FMedSci KEMRI | Wellcome Trust
	David Moher, PhD, FRSC, FCAHS University of Ottawa
	Nicholas DeVito, PhD Bennett Institute for Applied Data Science, Oxford