Webinar

Quality Defects and Methods of Reproducibility in Biomedical Research

Part 1: Tuesday, May 14 2024
Part 2: Tuesday May 21, 2024
12:00PM – 1:00PM

Registrants will receive the link to access their chosen webinar(s) after purchase.
A recording of the webinar will also be available to registrants after the livestream has taken place.

Concerns about non-reproducibility, uninformativeness, and serious quality defects are ubiquitous in biomedical research. The aims of this two-part webinar series are the following:

• to identify primary sources of non-reproducibility and uninformativeness
• to offer an array of recognition and prevention methods
• to recommend a curricular guide and literature sources for teaching methods of reproducibility as part of research education programs and mentored research career development programs.

The presentations will elucidate defects generated in the research from laboratories as well as defects that are imported from external sources. The discussions will equally cover research defects that are recognizable in the publication phase, and also defects that are non-discoverable by inspecting the final product. The conceptual information will be illustrated with copious examples and a list of specific sources of research defects. Tips and improvement tools will be presented for repetitive processes as well as the unique, research, specific sources of defects. The discussion will also cover the challenge of distinguishing reproducibility errors from biological variation that triggers unexpected discoveries.

This webinar is developed to support biomedical research laboratories, research universities and institutions, industry supported researchers, and funders of research projects in life sciences.

Webinar I
Quality Defects and Methods of Reproducibility in Biomedical Research
12:00 – 1:00 PM | Tuesday, May 14, 2024

Speakers:

Michael Lauer, MD
Andrew Balas, MD, PhD
Steven Goodman, MD, PhD
Ivan Oransky, MD

Webinar II
Quality Defects and Methods of Reproducibility in Biomedical Research
12:00 – 1:00 PM | Tuesday, May 21, 2024

Speakers:

• Anna Fine, PharmD, MS
• Peter Elkin, MD, MACP, FACMI, FNYAM
• Sarah Jenkins
• Nathalie Percie du Sert, PhD
• Chris Winchester

With thanks to our sponsor

• Part I

• Part II

• Speaker Biographies

12:00 – 1:00 PM May 14, 2024

• Opening plenary presentation on quality science and societal expectations
• Concepts of research quality and examples of defects
• Prevention of frequent research defects in the design phase
• Prevention of common research defects in the conduct phase

12:00 – 1:00 PM May 21, 2024

• Opening presentation on making preclinical and clinical research more trustworthy
• Prevention of frequent defects in clinical trials
• Sources of errors in preclinical laboratory studies
• Imported errors of research
• Quality control at the publication phase

	Andrew Balas, MD, PhD Andrew Balas MD, PhD is a Professor of Public Health at Augusta University, Vice President of the Friends of the NIH National Library of Medicine, member of the American College of Medical Informatics and elected member of the European Academy of Sciences and Arts. His studies about delay and waste in the transfer of research results to health care are frequent reference points in translational research initiatives. Currently, he leads the Biomedical Research Innovation Laboratory, a team of researchers conducting ‘science of science’ studies.
	Peter L. Elkin, MD, MACP, FACMI, FNYAM Dr. Elkin serves as Professor and Chair of the UB Department of Biomedical Informatics and Professor of Medicine at the University at Buffalo. He has over 120 publications, chaired multiple committees in health informatics, and authored the ANSI standard on Quality Indicators for Controlled Health Vocabularies. He has been a leader in research, education, and the development of standards in Biomedical Informatics since 1981.
	Anna Fine, PharmD, MS Anna M. Fine, PharmD, MS, is Acting Director of ClinicalTrials.gov at the National Center for Biotechnology Information, National Library of Medicine, NIH. She oversees technical, scientific, policy, regulatory, and outreach activities related to the operation of ClinicalTrials.gov, having served as deputy director since 2018.
	Steven Goodman, MD, PhD Steven Goodman is Associate Dean of Clinical and Translational Research and Professor at Stanford. He co-founded METRICS to improve reproducibility in biomedical research and leads SPORR to teach research rigor. He has served on numerous committees, authored key research, and was elected to the National Academy of Medicine in 2020.
	Sarah Jenkins Sarah Jenkins is Senior Director for Research Integrity & Publishing Ethics for Elsevier. She oversees policies, education, and tools to promote research integrity, ensuring ethical publication practices and supporting editors, publishing teams, and stakeholders globally.
	Michael Lauer, MD Michael Lauer is Deputy Director for Extramural Research at NIH, overseeing research quality and effectiveness. He has extensive experience in clinical epidemiology, big data analytics, and population health, having served at Cleveland Clinic and NHLBI, and has received numerous awards for his work.
	Ivan Oransky, MD Ivan Oransky is co-founder of Retraction Watch, editor in chief of The Transmitter, and distinguished journalist in residence at NYU. He has led editorial teams at major outlets and received awards for excellence in biomedical communication and science advocacy.
	Nathalie Percie du Sert, PhD Nathalie Percie du Sert is Head of Experimental Design and Reporting at the UK NC3Rs. She leads initiatives to improve preclinical research reliability and provides training, online resources, and tools such as the Experimental Design Assistant and ARRIVE guidelines. She holds a PhD from St George’s University of London.
	Chris Winchester Chris Winchester is CEO of Oxford PharmaGenesis, a global HealthScience communications consultancy. He has co-authored numerous studies and is a co-founder of Open Pharma, a Director of the Oxford Health Policy Forum, and past Chair of the International Society for Medical Publication Professionals.